Wuhu Decoction Regulates Dendritic Cell Autophagy in the Treatment of Respiratory Syncytial Virus (RSV)-Induced Mouse Asthma by AMPK/ULK1 Signaling Pathway
Identifieur interne : 000272 ( Main/Exploration ); précédent : 000271; suivant : 000273Wuhu Decoction Regulates Dendritic Cell Autophagy in the Treatment of Respiratory Syncytial Virus (RSV)-Induced Mouse Asthma by AMPK/ULK1 Signaling Pathway
Auteurs : Xingyu Chen [République populaire de Chine] ; Yinhe Luo [République populaire de Chine] ; Mengqing Wang [République populaire de Chine] ; Le Sun [République populaire de Chine] ; Kailing Huang [République populaire de Chine] ; Yan Li [République populaire de Chine] ; Yingying Chen [République populaire de Chine] ; Yi Ding [République populaire de Chine] ; Xin Zhang [République populaire de Chine] ; Luojia Jiao [République populaire de Chine] ; Jingyi Yang [République populaire de Chine] ; Ting Huang [République populaire de Chine]Source :
- Medical Science Monitor : International Medical Journal of Experimental and Clinical Research [ 1234-1010 ] ; 2019.
Abstract
Dendritic cell autophagy plays a pivotal role in asthma. Wuhu decoction can significantly improve respiratory syncytial virus (RSV) bronchiolitis and delay its development into asthma. The aim of the present study was to explore the therapeutic effect and mechanism of Wuhu decoction on RSV -induced asthma in mice.
Establishment of asthmatic mice model was induced by RSV. Hematoxylin-eosin staining, periodic acid-Schiff (PAS) staining, and Masson trichrome staining were performed to observe pathological changes in the lungs. The levels of CD4+ T, CD8+ T, and CD4+ CD25+ T in blood were analyzed by flow cytometry. The contents of interleukin (IL)-4, interferon-gamma (IFN-γ), IL-10, and IL-13 in serum were measured by enzyme-linked immunosorbent assay (ELISA). The number of autophagosomes in dendritic cells (DCs) of lung tissue was observed by transmission electron microscope. The DCs of lung tissue were isolated by magnetic bead sorting. The levels of LC3-II, Beclin-1, and LC3-I in DCs and MMP-9, TIMP-1, AMPK, p-AMPK, ULK1, and LK1 expression in lung tissues were detected by western blot. Real-time polymerase chain reaction (PCR) detected the expression of AMPK and ULK1 genes.
Wuhu decoction can effectively alleviate chronic airway inflammation and airway remodeling and reduce airway hyperresponsiveness. Moreover, Wuhu decoction can significantly enhance the level of autophagy in DCs of lung tissue and promote the expression of AMPK and ULK1 in lung tissue.
Wuhu decoction may improve the RSV-induced asthmatic symptoms by enhancing autophagy of DCs in lung tissue dependent on the AMPK/ULK1 signaling pathway.
Url:
DOI: 10.12659/MSM.917692
PubMed: 31325378
PubMed Central: 6662944
Affiliations:
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Hunan University of Chinese Medicine, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Xin" sort="Zhang, Xin" uniqKey="Zhang X" first="Xin" last="Zhang">Xin Zhang</name><affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-25-5389">Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Hunan University of Chinese Medicine, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Jiao, Luojia" sort="Jiao, Luojia" uniqKey="Jiao L" first="Luojia" last="Jiao">Luojia Jiao</name><affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-25-5389">Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Hunan University of Chinese Medicine, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Jingyi" sort="Yang, Jingyi" uniqKey="Yang J" first="Jingyi" last="Yang">Jingyi Yang</name><affiliation wicri:level="1"><nlm:aff id="af3-medscimonit-25-5389">The Domestic First-Class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>The Domestic First-Class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Ting" sort="Huang, Ting" uniqKey="Huang T" first="Ting" last="Huang">Ting Huang</name><affiliation wicri:level="1"><nlm:aff id="af3-medscimonit-25-5389">The Domestic First-Class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>The Domestic First-Class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31325378</idno><idno type="pmc">6662944</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662944</idno><idno type="RBID">PMC:6662944</idno><idno type="doi">10.12659/MSM.917692</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000693</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000693</idno><idno type="wicri:Area/Pmc/Curation">000693</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000693</idno><idno type="wicri:Area/Pmc/Checkpoint">000237</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000237</idno><idno type="wicri:Area/Ncbi/Merge">000821</idno><idno type="wicri:Area/Ncbi/Curation">000821</idno><idno type="wicri:Area/Ncbi/Checkpoint">000821</idno><idno type="wicri:doubleKey">1234-1010:2019:Chen X:wuhu:decoction:regulates</idno><idno type="wicri:Area/Main/Merge">000272</idno><idno type="wicri:Area/Main/Curation">000272</idno><idno type="wicri:Area/Main/Exploration">000272</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Wuhu Decoction Regulates Dendritic Cell Autophagy in the Treatment of Respiratory Syncytial Virus (RSV)-Induced Mouse Asthma by AMPK/ULK1 Signaling Pathway</title><author><name sortKey="Chen, Xingyu" sort="Chen, Xingyu" uniqKey="Chen X" first="Xingyu" last="Chen">Xingyu Chen</name><affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-25-5389">Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Hunan University of Chinese Medicine, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Luo, Yinhe" sort="Luo, Yinhe" uniqKey="Luo Y" first="Yinhe" last="Luo">Yinhe Luo</name><affiliation wicri:level="1"><nlm:aff id="af2-medscimonit-25-5389">College of Integrated Traditional Chinese and Western Medicine of Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>College of Integrated Traditional Chinese and Western Medicine of Hunan University of Chinese Medicine, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Mengqing" sort="Wang, Mengqing" uniqKey="Wang M" first="Mengqing" last="Wang">Mengqing Wang</name><affiliation wicri:level="1"><nlm:aff id="af3-medscimonit-25-5389">The Domestic First-Class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>The Domestic First-Class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Le" sort="Sun, Le" uniqKey="Sun L" first="Le" last="Sun">Le Sun</name><affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-25-5389">Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Hunan University of Chinese Medicine, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Kailing" sort="Huang, Kailing" uniqKey="Huang K" first="Kailing" last="Huang">Kailing Huang</name><affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-25-5389">Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Hunan University of Chinese Medicine, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-25-5389">Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Hunan University of Chinese Medicine, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yingying" sort="Chen, Yingying" uniqKey="Chen Y" first="Yingying" last="Chen">Yingying Chen</name><affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-25-5389">Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Hunan University of Chinese Medicine, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Ding, Yi" sort="Ding, Yi" uniqKey="Ding Y" first="Yi" last="Ding">Yi Ding</name><affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-25-5389">Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Hunan University of Chinese Medicine, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Xin" sort="Zhang, Xin" uniqKey="Zhang X" first="Xin" last="Zhang">Xin Zhang</name><affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-25-5389">Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Hunan University of Chinese Medicine, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Jiao, Luojia" sort="Jiao, Luojia" uniqKey="Jiao L" first="Luojia" last="Jiao">Luojia Jiao</name><affiliation wicri:level="1"><nlm:aff id="af1-medscimonit-25-5389">Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Hunan University of Chinese Medicine, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Jingyi" sort="Yang, Jingyi" uniqKey="Yang J" first="Jingyi" last="Yang">Jingyi Yang</name><affiliation wicri:level="1"><nlm:aff id="af3-medscimonit-25-5389">The Domestic First-Class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>The Domestic First-Class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Ting" sort="Huang, Ting" uniqKey="Huang T" first="Ting" last="Huang">Ting Huang</name><affiliation wicri:level="1"><nlm:aff id="af3-medscimonit-25-5389">The Domestic First-Class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>The Domestic First-Class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Medical Science Monitor : International Medical Journal of Experimental and Clinical Research</title><idno type="ISSN">1234-1010</idno><idno type="eISSN">1643-3750</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Dendritic cell autophagy plays a pivotal role in asthma. Wuhu decoction can significantly improve respiratory syncytial virus (RSV) bronchiolitis and delay its development into asthma. The aim of the present study was to explore the therapeutic effect and mechanism of Wuhu decoction on RSV -induced asthma in mice.</p></sec><sec><title>Material/Methods</title><p>Establishment of asthmatic mice model was induced by RSV. Hematoxylin-eosin staining, periodic acid-Schiff (PAS) staining, and Masson trichrome staining were performed to observe pathological changes in the lungs. The levels of CD4<sup>+</sup> T, CD8<sup>+</sup> T, and CD4<sup>+</sup> CD25<sup>+</sup> T in blood were analyzed by flow cytometry. The contents of interleukin (IL)-4, interferon-gamma (IFN-γ), IL-10, and IL-13 in serum were measured by enzyme-linked immunosorbent assay (ELISA). The number of autophagosomes in dendritic cells (DCs) of lung tissue was observed by transmission electron microscope. The DCs of lung tissue were isolated by magnetic bead sorting. The levels of LC3-II, Beclin-1, and LC3-I in DCs and MMP-9, TIMP-1, AMPK, p-AMPK, ULK1, and LK1 expression in lung tissues were detected by western blot. Real-time polymerase chain reaction (PCR) detected the expression of AMPK and ULK1 genes.</p></sec><sec><title>Results</title><p>Wuhu decoction can effectively alleviate chronic airway inflammation and airway remodeling and reduce airway hyperresponsiveness. Moreover, Wuhu decoction can significantly enhance the level of autophagy in DCs of lung tissue and promote the expression of AMPK and ULK1 in lung tissue.</p></sec><sec><title>Conclusions</title><p>Wuhu decoction may improve the RSV-induced asthmatic symptoms by enhancing autophagy of DCs in lung tissue dependent on the AMPK/ULK1 signaling pathway.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Furuta, T" uniqKey="Furuta T">T Furuta</name></author><author><name sortKey="Hasegawa, S" uniqKey="Hasegawa S">S Hasegawa</name></author><author><name sortKey="Mizutani, M" uniqKey="Mizutani M">M Mizutani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, C" uniqKey="Shi C">C Shi</name></author><author><name sortKey="Xue, W" uniqKey="Xue W">W Xue</name></author><author><name sortKey="Han, B" uniqKey="Han B">B Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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uniqKey="Wang L">L Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Js" uniqKey="Lee J">JS Lee</name></author><author><name sortKey="Park, Sj" uniqKey="Park S">SJ Park</name></author><author><name sortKey="Cho, Ys" uniqKey="Cho Y">YS Cho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Cs" uniqKey="Park C">CS Park</name></author><author><name sortKey="Bang, Br" uniqKey="Bang B">BR Bang</name></author><author><name sortKey="Kwon, Hs" uniqKey="Kwon H">HS Kwon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Egan, Df" uniqKey="Egan D">DF Egan</name></author><author><name sortKey="Shackelford, Db" uniqKey="Shackelford D">DB Shackelford</name></author><author><name sortKey="Mihaylova, Mm" uniqKey="Mihaylova M">MM Mihaylova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petherick, Kj" uniqKey="Petherick K">KJ Petherick</name></author><author><name sortKey="Conway, Oj" uniqKey="Conway O">OJ Conway</name></author><author><name sortKey="Mpamhanga, C" uniqKey="Mpamhanga C">C Mpamhanga</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Chen, Xingyu" sort="Chen, Xingyu" uniqKey="Chen X" first="Xingyu" last="Chen">Xingyu Chen</name></noRegion><name sortKey="Chen, Yingying" sort="Chen, Yingying" uniqKey="Chen Y" first="Yingying" last="Chen">Yingying Chen</name><name sortKey="Ding, Yi" sort="Ding, Yi" uniqKey="Ding Y" first="Yi" last="Ding">Yi Ding</name><name sortKey="Huang, Kailing" sort="Huang, Kailing" uniqKey="Huang K" first="Kailing" last="Huang">Kailing Huang</name><name sortKey="Huang, Ting" sort="Huang, Ting" uniqKey="Huang T" first="Ting" last="Huang">Ting Huang</name><name sortKey="Jiao, Luojia" sort="Jiao, Luojia" uniqKey="Jiao L" first="Luojia" last="Jiao">Luojia Jiao</name><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><name sortKey="Luo, Yinhe" sort="Luo, Yinhe" uniqKey="Luo Y" first="Yinhe" last="Luo">Yinhe Luo</name><name sortKey="Sun, Le" sort="Sun, Le" uniqKey="Sun L" first="Le" last="Sun">Le Sun</name><name sortKey="Wang, Mengqing" sort="Wang, Mengqing" uniqKey="Wang M" first="Mengqing" last="Wang">Mengqing Wang</name><name sortKey="Yang, Jingyi" sort="Yang, Jingyi" uniqKey="Yang J" first="Jingyi" last="Yang">Jingyi Yang</name><name sortKey="Zhang, Xin" sort="Zhang, Xin" uniqKey="Zhang X" first="Xin" last="Zhang">Xin Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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